Capnocytophaga canimorsus is a bacterial cause of fulminant sepsis among individuals who have been bitten by a dog. Pdf capnocytophaga species belong to the oral microbiota but are not a common cause of infection in febrile neutropenia. The production and properties of an aminopeptidase from capnocytophaga gingivalis were studied. Pneumonia and sepsis due to fluoroquinoloneresistant.
Atsutoshi yoshimura department of periodontology, nagasaki university school of dentistry, 171 sakamoto, nagasaki 8528588, japan. Bacteremia caused by capnocytophaga species in patients with. Get a printable copy pdf file of the complete article 796k, or click on a page. Detection and prevalence of capnocytophaga in periodontal health. Porphyromonas gingivalis and capnocytophaga ochracea are antagonists for human tolllike receptor 4 atsutoshi yoshimura, 1 takashi kaneko, yoshifumi kato, douglas t.
Theirstudiessuggest that this genus includes at least three distinct biogroups. We present two cases of infection caused by capnocytophaga ochracea. Although occasionally found in soil and water, the predominant natural habitat of capnocytophaga species is the human oropharynx. Ninetyseven strains of capnocytophaga isolated from the oral cavity and the type strains of c. Capnocytophaga canimorsus article about capnocytophaga. Lipopolysaccharides from periodontopathic bacteria porphyromonas gingivalis and capnocytophaga ochracea are an tagonists for human tolllike receptor 4. Get a printable copy pdf file of the complete article 4. Capnocytophaga sputigena bacteremia in a patient with. The word element capno in the bacteriums name refers to its ability to survive in high levels of carbon dioxide. The genus initially included three species on the basis of morphological, physiological and dna data. Capnocytophaga ochracea, capnocytophaga sputigena and capnocytophaga gingivalis. Clinical findings c gingivalis may cause periodontal disease or, in immune compromised hosts e. In addition, they are opportunistic pathogens associated with periodontal diseases and animal bites, causing systemic infection in both immunocompetent and immunocompromised hosts 2, 3.
It is a commensal bacterium in the normal gingival flora of canine and feline species, but can cause illness in humans. Capnocytophaga ochracea, capnocytophaga sputigena, and capnocytophaga gingivalis. Oral cancer and epithelial precursor lesions are also linked with bacteria from genera fusobacterium, veillonella, actinomyces, clostridium, haemophilus, and enterobacteriaceae 14. May 16, 2020 capnocytophaga canimorsus is a type of bacteria that exists in the mouths of healthy dogs and cats.
Article information, pdf download for microbial pathogenicity. Sixtyeight strains of capnophilic fusiform gramnegative rods from the human oral cavity were subjected to extensive physiologic characterization, tested for susceptibility to various antibiotics, and the molpercent guanine plus cytosine of each isolate determined. Pdf capnocytophaga sputigena bacteremia in a neutropenic host. Microscopy of capnocytophaga sputigena, capnocytophaga gingivalis, and capnocytophaga ochracea, infect immun 26. Emended description of capnocytophaga gingivalis free. Capnocytophaga granulosa and capnocytophaga haemolytica. Capnocytophaga gingivalis 2010 was monitored optically at 540 nm. The capnocytophaga germs that are common in dogs and cats can be spread to people through a bite or after close contact with dogs or cats. The genus consists of seven species, namely capnocytophaga gingivalis, c.
Capnocytophaga are gramnegative, facultative anaerobic bacteria. Bacteria of the genus capnocytophaga are recently recognised pathogens which may cause oral disease and subsequent septicaemia in the immunocompromised host. Detection, identification, comparison capnocytophaga, bacteroides. Hence, most studies to date have reported these isolates as. Aug 15, 2001 capnocytophaga species are a rare cause of bacteremia in patients with neutropenia and cancer. Microscopy of capnocytophaga sputigena, capnocytophaga. The susceptibilities of the 43 capnocytophaga strains to three betalactam antibiotics and three betalactamase inhibitors, alone or in combination, expressed as the range of mics and the mics at which 50% mic 50 and 90% mic 90 of the strains are inhibited, are shown in table table1. Many kinds of bacteria germs called capnocytophaga live in the mouths of dogs and cats. Clinical isolates of capnocytophaga spp are classified into two broad groups. See the preventing dog bites page for information on how to prevent dog bites and what to do if you are bitten, regardless of your health status. Effects of glucose concentration on growth and hydrolytic enzyme production article pdf available in microbiology 142 pt 88.
The frequency with which these bacteria have been isolated in large patient series ranges from 0. The data suggest that the glucose is catabolized by a fully aerobic route. The genus capnocytophaga includes three bacterial species. Here, we show that tn 4351, derived from bacteroides fragilis, could be. Capnocytophaga is a genus of gramnegative bacteria. Download fulltext pdf capnocytophaga gingivalis aminopeptidase. Capnocytophaga canimorsus is the species most commonly involved in zoonotic. Aclq0000 capnocytophaga gingivalis atcc 33624, whole genome shotgun sequencing project. In vitro susceptibilities of capnocytophaga isolates to. Antimicrobial treatment of capnocytophaga infections.
They were the earliest bacteria to be isolated and named from the human subgingival plaque. Capnocytophaga ochracea is an aerotolerant anaerobe that requires either an anaerobic environment or 5% co2 concentration of the gaseous form or 20 mm hco3 in the hydrated form 7. Rarely, capnocytophaga germs can spread to people through bites, scratches, or close contact from a dog or cat and may cause illness, including sepsis. This bacteria can cause sepsis in people after an animal bite. Normally found in the oropharyngeal tract of mammals, they are involved in the pathogenesis of some animal bite wounds and periodontal diseases. Keratocyst capnocytophaga superinfection rua gonzalvez. Capnocytophaga spp consists of facultative anaerobic gram.
Ab032576 capnocytophaga gingivalis gyrb gene for dna gyrase b subunit, partial cds. Golenbock,2 and yoshitaka hara1 department of periodontology, nagasaki university school of dentistry, 171 sakamoto, nagasaki 8528588, japan,1. A potential virulence factor article pdf available in microbiology 141 pt 1212. Lysozymemediated aggregation and lysis ofthe periodontal. Infections are more often linked to dog bites or dog contact. The subacute presentation of the monoarthritis with this organism of low virulence led. Capnocytophaga species infectious disease and antimicrobial. Capnocytophaga canimorsus is a fastidious, slowgrowing, gramnegative rod of the genus capnocytophaga. Pyogenic arthritis caused by capnocytophaga gingivalis in an. Microorganism capnocytophaga gingivalis 2010 infection and.
Human oral capnocytophaga species have been only rarely described as a cause of sepsis in patients following stem cell or marrow transplantation, and pneumonia has not been reported in this setting. Capnocytophaga synonyms, capnocytophaga pronunciation, capnocytophaga translation, english dictionary definition of capnocytophaga. This pathogen has a unique shape and outer layer, and can cause severe illness if not treated quickly and. Emended description of capnocytophaga gingivalis microbiology. What is capnocytophaga how common is capnocytophaga. People with a weakened immune systems who have difficulty fighting off infections for example, people with cancer or those. Capnocytophaga ochracer, capnocytophaga sputigena, capnocytophaga gingivalis, capnocytophaga granulose, and capnocytophaga heamolytica. It is rod shaped and is able to grow rapidly under the right conditions. Lipopolysaccharides from periodontopathic bacteria.
Due to the low level of evolutionary relationship to proteobacteria, genetic methods suitable for the genus capnocytophaga needed to be established. Most people who have contact with a dog or cat do not become sick. Capnocytophaga species are facultative anaerobic, capnophilic, fusiform, gramnegative bacilli exhibiting gliding motility. A gramnegative, microaerophilic, co2requiring gliding bacillus, which is found in normal oral flora and an opportunistic pathogen. Pdf identification of capnocytophaga species from oral cavity of. Capnocytophaga canimorsus formerly cdc group df2 and capnocytophaga cynodegmi cdc group df2 like were proposed as two new species 1. Although the genus is known to contain five human oral isolates, accurate identification to species level of these organisms recovered from subgingival plaque has been hampered by the lack of a reliable method. Transmission may occur through bites, licks, or even close proximity with animals. A genus of bacteria comprising fusiform, fermentative, gramnegative rods which require carbon dioxide for growth and show gliding motility explanation of capnocytophaga canimorsus. The characteristics of the isolates were compared with 10 fresh and 2 stock isolates of fusobacterium nucleatum. Microbial pathogenicity blackpigmented bacteroides species.
In chemostat culture, the microaerophilic, co 2 requiring, gingivalplaqueassociated bacterium capnocytophaga gingivalis responded to the addition of glucose 16 g i1 by doubling its growth rate and increasing its biomass yield fivefold. Capnocytophaga gingivalis definition of capnocytophaga. Completion of the reaction was determined spectrophotometrically from the. Assessment of five culture media for the growth and isolation of. Thisdesignation is aptfor all ofthese strains, andweconcurwithsocranskyetal. Many works have also shown that oral pathogens are essential in the development of colorectal and pancreatic. Capnocytophaga definition of capnocytophaga by medical. Capnocytophaga species have been implicated as putative periodontal pathogens. Antibiotic content of selective culture media for isolation.
Genetic tools for studying capnocytophaga canimorsus. The first group is made up of the two species located in animal oral cavities and the second one is formed by the seven human species capnocytophaga ochracea, capnocytophaga sputigena, capnocytophaga gingivalis, capnocytophaga granulosa, capnocytophaga. To view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Find out information about capnocytophaga canimorsus. Capnocytophaga definition of capnocytophaga by the free. Capnocytophaga is the name of a group of gramnegative bacteria that live in the mouth of some animals and humans. Capnocytophaga canimorsus, a commensal bacterium from canine oral flora, has been isolated throughout the world from severe human infections caused by dog bites.
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